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Preparation of tablets
One knows that a tablet is the most common form of medication for the administering of drugs in a dry state. Its preparation consti¬tutes an important part of modem “Pharmaceutical Technology”. The method of tablet making or tabletting is defined as a process of pres¬sure of powdered medicine.
It is generally observed that some tablets are made easier from certain drugs than from other ones. For example, sodium chloride is used without the addition of auxiliary substances. But for lactose the addition of such substances is necessary to overcome certain difficul¬ties. It is interesting that in the process of tabletting some materials are continuously binding and sticking in the special machine. Stick¬ing takes place when there is too much moisture in the granules be¬cause of insufficient drying, etc.
The application of different pressure during tabletting plays a very great role. It is important that tablets which are being dissolved slowly by saliva in the mouth are more strongly compressed than other ones using for common internal administration. Another important effect of higher pressures is an increase of friction which causes the use of greater amount of lubricating and gliding substances, such as natural starch. The use of starch as an auxiliary component in tablet making is generally recognized. It was stated that starches possessed very good gliding properties and didn’t show any lubricating action.
Задание 2. Дайте ответы на английском языке.
1. How is the method of tablet making defined?
2. What is the difference between the use of sodium chloride and lactose?
3. How many lubricating and gliding substances are used and where?
4. What properties did starches possess?
5. Where are some materials continuously binding and sticking?
6. What is tablet?
7. Why does sticking take place?
8. How are more strongly compressed tablets being dissolved in the mouth?
9. What plays a very important role in tablet making?
10. What can you tell about the use of starch in tabletting?
Preparation of tablets
One knows that a tablet is the most common form of medication for the administering of drugs in a dry state. Its preparation consti¬tutes an important part of modem “Pharmaceutical Technology”. The method of tablet making or tabletting is defined as a process of pres¬sure of powdered medicine.
It is generally observed that some tablets are made easier from certain drugs than from other ones. For example, sodium chloride is used without the addition of auxiliary substances. But for lactose the addition of such substances is necessary to overcome certain difficul¬ties. It is interesting that in the process of tabletting some materials are continuously binding and sticking in the special machine. Stick¬ing takes place when there is too much moisture in the granules be¬cause of insufficient drying, etc.
The application of different pressure during tabletting plays a very great role. It is important that tablets which are being dissolved slowly by saliva in the mouth are more strongly compressed than other ones using for common internal administration. Another important effect of higher pressures is an increase of friction which causes the use of greater amount of lubricating and gliding substances, such as natural starch. The use of starch as an auxiliary component in tablet making is generally recognized. It was stated that starches possessed very good gliding properties and didn’t show any lubricating action.
Задание 2. Дайте ответы на английском языке.
1. How is the method of tablet making defined?
2. What is the difference between the use of sodium chloride and lactose?
3. How many lubricating and gliding substances are used and where?
4. What properties did starches possess?
5. Where are some materials continuously binding and sticking?
6. What is tablet?
7. Why does sticking take place?
8. How are more strongly compressed tablets being dissolved in the mouth?
9. What plays a very important role in tablet making?
10. What can you tell about the use of starch in tabletting?
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Answers & Comments
Подготовка таблеток
Каждый знает, что таблетка - наиболее распространенная форма лечения для управления наркотиков в сухом штате. Его подготовка consti¬tutes важная часть модема “Фармацевтическая Технология”. Метод создания таблетки или tabletting определен как процесс pres¬sure порошкообразной медицины.
Обычно замечается, что некоторые таблетки сделаны легче из определенных наркотиков, чем от других. Например, поваренная соль используется без добавления вспомогательных веществ. Но для лактозы добавление таких веществ необходимо, чтобы преодолеть определенный difficul¬ties. Интересно, что в процессе tabletting некоторые материалы непрерывно связывают и всовывают специальную машину. Stick¬ing имеет место, когда есть слишком много влажности в гранулах be¬cause недостаточного высыхания и т.д.
Применение различного давления во время tabletting играет очень большую роль. Важно, чтобы таблетки, которые расторгаются медленно слюной во рту, были более сильно сжаты, чем другое использование для общей внутренней администрации. Другой важный эффект более высоких давлений - увеличение трения, которое вызывает использование большей суммы смазки и скользящих веществ, таких как естественный крахмал. Использование крахмала как вспомогательный компонент в создании таблетки обычно признается. Было заявлено, что крахмалы обладали очень хорошими скользящими свойствами и не показывали смазочного действия.