Ответ:

1) Mozart and Beethoven/design/machines? (✗ compose music)

— Did Mozart and Beethoven design machines?

— No, the didn't design machines. They composed music.

2) Sir Alexander Fleming/discover/penicillin? (✓)

— Did Sir Alexander Fleming discover penicillin?

— Yes, Sir Alexander Fleming discovered penicillin.

3) Thomas Edison/study/plants? (✗ invent/the light bulb)

— Did Thomas Edison study plants?

— No, Thomas Edison didn't study plants. He invented the light bulb.

4) The Wright brothers/invent/the first modern aeroplane? (✓)

— Did The Wright brothers invent the first modern aeroplane?

— Yes, the Wright brothers invented the first modern aeroplane.